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    ์‚ฌ๋ฌผ์ธํ„ฐ๋„ท์„ ์œ„ํ•œ ๋ฌด์„  ์‹ค๋‚ด ์ธก์œ„ ์•Œ๊ณ ๋ฆฌ์ฆ˜

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    ํ•™์œ„๋…ผ๋ฌธ(๋ฐ•์‚ฌ) -- ์„œ์šธ๋Œ€ํ•™๊ต๋Œ€ํ•™์› : ๊ณต๊ณผ๋Œ€ํ•™ ์ „๊ธฐยท์ •๋ณด๊ณตํ•™๋ถ€, 2022.2. ๊น€์„ฑ์ฒ .์‹ค๋‚ด ์œ„์น˜ ๊ธฐ๋ฐ˜ ์„œ๋น„์Šค๋Š” ์Šค๋งˆํŠธํฐ์„ ์ด์šฉํ•œ ์‹ค๋‚ด์—์„œ์˜ ๊ฒฝ๋กœ์•ˆ๋‚ด, ์Šค๋งˆํŠธ ๊ณต์žฅ์—์„œ์˜ ์ž์› ๊ด€๋ฆฌ, ์‹ค๋‚ด ๋กœ๋ด‡์˜ ์ž์œจ์ฃผํ–‰ ๋“ฑ ๋งŽ์€ ๋ถ„์•ผ์— ์ ‘๋ชฉ๋  ์ˆ˜ ์žˆ์œผ๋ฉฐ, ์‚ฌ๋ฌผ์ธํ„ฐ๋„ท ์‘์šฉ์—๋„ ํ•„์ˆ˜์ ์ธ ๊ธฐ์ˆ ์ด๋‹ค. ๋‹ค์–‘ํ•œ ์œ„์น˜ ๊ธฐ๋ฐ˜ ์„œ๋น„์Šค๋ฅผ ๊ตฌํ˜„ํ•˜๊ธฐ ์œ„ํ•ด์„œ๋Š” ์ •ํ™•ํ•œ ์œ„์น˜ ์ •๋ณด๊ฐ€ ํ•„์š”ํ•˜๋ฉฐ, ์ ํ•ฉํ•œ ๊ฑฐ๋ฆฌ ๋ฐ ์œ„์น˜๋ฅผ ์ถ”์ • ๊ธฐ์ˆ ์ด ํ•ต์‹ฌ์ ์ด๋‹ค. ์•ผ์™ธ์—์„œ๋Š” ์œ„์„ฑํ•ญ๋ฒ•์‹œ์Šคํ…œ์„ ์ด์šฉํ•ด์„œ ์œ„์น˜ ์ •๋ณด๋ฅผ ํš๋“ํ•  ์ˆ˜ ์žˆ๋‹ค. ๋ณธ ํ•™์œ„๋…ผ๋ฌธ์—์„œ๋Š” ์™€์ดํŒŒ์ด ๊ธฐ๋ฐ˜ ์ธก์œ„ ๊ธฐ์ˆ ์— ๋Œ€ํ•ด ๋‹ค๋ฃฌ๋‹ค. ๊ตฌ์ฒด์ ์œผ๋กœ, ์ „ํŒŒ์˜ ์‹ ํ˜ธ ์„ธ๊ธฐ ๋ฐ ๋„๋‹ฌ ์‹œ๊ฐ„์„ ์ด์šฉํ•œ ์ •๋ฐ€ํ•œ ์‹ค๋‚ด ์œ„์น˜ ์ถ”์ •์„ ์œ„ํ•œ ์„ธ ๊ฐ€์ง€ ๊ธฐ์ˆ ์— ๋Œ€ํ•ด ๋‹ค๋ฃฌ๋‹ค. ๋จผ์ €, ๋น„๊ฐ€์‹œ๊ฒฝ๋กœ ํ™˜๊ฒฝ์—์„œ์˜ ๊ฑฐ๋ฆฌ ์ถ”์ • ์ •ํ™•๋„๋ฅผ ํ–ฅ์ƒ์‹œ์ผœ ๊ฑฐ๋ฆฌ ๊ธฐ๋ฐ˜ ์ธก์œ„์˜ ์ •ํ™•๋„๋ฅผ ํ–ฅ์ƒ์‹œํ‚ค๋Š” ํ•˜์ด๋ธŒ๋ฆฌ๋“œ ์•Œ๊ณ ๋ฆฌ์ฆ˜์„ ์ œ์•ˆํ•œ๋‹ค. ์ œ์•ˆํ•˜ ์•Œ๊ณ ๋ฆฌ์ฆ˜์€๋“€์–ผ ๋ฐด๋“œ ๋Œ€์—ญ์˜ ์‹ ํ˜ธ์„ธ๊ธฐ๋ฅผ ๊ฐ์‡„๋Ÿ‰์„ ์ธก์ •ํ•˜์—ฌ ๊ฑฐ๋ฆฌ ๊ธฐ๋ฐ˜ ์ธก์œ„ ๊ธฐ๋ฒ•์„ ์ ์šฉํ•  ๋•Œ, ๊ฑฐ๋ฆฌ ์ถ”์ •๋ถ€ ๋‹จ๊ณ„๋งŒ์„ ๋ฐ์ดํ„ฐ ๊ธฐ๋ฐ˜ ํ•™์Šต์„ ์ด์šฉํ•œ ๊นŠ์€ ์‹ ๊ฒฝ๋ง ํšŒ๊ท€ ๋ชจ๋ธ๋กœ ๋Œ€์ฒดํ•œ ๋ฐฉ์•ˆ์ด๋‹ค. ์ ์ ˆํžˆ ํ•™์Šต๋œ ๊นŠ์€ ํšŒ๊ท€ ๋ชจ๋ธ์˜ ์‚ฌ์šฉ์œผ๋กœ ๋น„๊ฐ€์‹œ๊ฒฝ๋กœ ํ™˜๊ฒฝ์—์„œ ๋ฐœ์ƒํ•˜๋Š” ๊ฑฐ๋ฆฌ ์ถ”์ • ์˜ค์ฐจ๋ฅผ ํšจ๊ณผ์ ์œผ๋กœ ๊ฐ์†Œ์‹œํ‚ฌ ์ˆ˜ ์žˆ์œผ๋ฉฐ, ๊ฒฐ๊ณผ์ ์œผ๋กœ ์œ„์น˜ ์ถ”์ • ์˜ค์ฐจ ๋˜ํ•œ ๊ฐ์†Œ์‹œ์ผฐ๋‹ค. ์ œ์•ˆํ•œ ๋ฐฉ๋ฒ•์„ ์‹ค๋‚ด ๊ด‘์„ ์ถ”์  ๊ธฐ๋ฐ˜ ๋ชจ์˜์‹คํ—˜์œผ๋กœ ํ‰๊ฐ€ํ–ˆ์„ ๋•Œ, ๊ธฐ์กด ๊ธฐ๋ฒ•๋“ค์— ๋น„ํ•ด์„œ ์œ„์น˜ ์ถ”์ • ์˜ค์ฐจ๋ฅผ ์ค‘๊ฐ„๊ฐ’์„ ๊ธฐ์ค€์œผ๋กœ 22.3% ์ด์ƒ ์ค„์ผ ์ˆ˜ ์žˆ์Œ์„ ๊ฒ€์ฆํ–ˆ๋‹ค. ์ถ”๊ฐ€์ ์œผ๋กœ, ์ œ์•ˆํ•œ ๋ฐฉ๋ฒ•์€ ์‹ค๋‚ด์—์„œ์˜ AP ์œ„์น˜๋ณ€ํ™” ๋“ฑ์— ๊ฐ•์ธํ•จ์„ ํ™•์ธํ–ˆ๋‹ค. ๋‹ค์Œ์œผ๋กœ, ๋ณธ ๋…ผ๋ฌธ์—์„œ๋Š” ๋น„๊ฐ€์‹œ๊ฒฝ๋กœ์—์„œ ๋‹จ์ผ ๋Œ€์—ญ ์ˆ˜์‹ ์‹ ํ˜ธ์„ธ๊ธฐ๋ฅผ ์ธก์ •ํ–ˆ์„ ๋•Œ ๋น„๊ฐ€์‹œ๊ฒฝ๋กœ๊ฐ€ ๋งŽ์€ ์‹ค๋‚ด ํ™˜๊ฒฝ์—์„œ ์œ„์น˜ ์ถ”์ • ์ •ํ™•๋„๋ฅผ ๋†’์ด๊ธฐ ์œ„ํ•œ ๋ฐฉ์•ˆ์„ ์ œ์•ˆํ•œ๋‹ค. ๋‹จ์ผ ๋Œ€์—ญ ์ˆ˜์‹ ์‹ ํ˜ธ์„ธ๊ธฐ๋ฅผ ์ด์šฉํ•˜๋Š” ๋ฐฉ์•ˆ์€ ๊ธฐ์กด์— ์ด์šฉ๋˜๋Š” ์™€์ดํŒŒ์ด, ๋ธ”๋ฃจํˆฌ์Šค, ์ง๋น„ ๋“ฑ์˜ ๊ธฐ๋ฐ˜์‹œ์„ค์— ์‰ฝ๊ฒŒ ์ ์šฉ๋  ์ˆ˜ ์žˆ๊ธฐ ๋•Œ๋ฌธ์— ๋„๋ฆฌ ์ด์šฉ๋œ๋‹ค. ํ•˜์ง€๋งŒ ์‹ ํ˜ธ ์„ธ๊ธฐ์˜ ๋‹จ์ผ ๊ฒฝ๋กœ์†์‹ค ๋ชจ๋ธ์„ ์ด์šฉํ•œ ๊ฑฐ๋ฆฌ ์ถ”์ •์€ ์ƒ๋‹นํ•œ ์˜ค์ฐจ๋ฅผ ์ง€๋…€์„œ ์œ„์น˜ ์ถ”์ • ์ •ํ™•๋„๋ฅผ ๊ฐ์†Œ์‹œํ‚จ๋‹ค. ์ด๋Ÿฌํ•œ ๋ฌธ์ œ์˜ ์›์ธ์€ ๋‹จ์ผ ๊ฒฝ๋กœ์†์‹ค ๋ชจ๋ธ๋กœ๋Š” ์‹ค๋‚ด์—์„œ์˜ ๋ณต์žกํ•œ ์ „ํŒŒ ์ฑ„๋„ ํŠน์„ฑ์„ ๋ฐ˜์˜ํ•˜๊ธฐ ์–ด๋ ต๊ธฐ ๋•Œ๋ฌธ์ด๋‹ค. ๋ณธ ์—ฐ๊ตฌ์—์„œ๋Š” ์‹ค๋‚ด ์œ„์น˜ ์ถ”์ •์„ ์œ„ํ•œ ๋ชฉ์ ์œผ๋กœ, ์ค‘์ฒฉ๋œ ๋‹ค์ค‘ ์ƒํƒœ ๊ฒฝ๋กœ ๊ฐ์‡„ ๋ชจ๋ธ์„ ์ƒˆ๋กญ๊ฒŒ ์ œ์‹œํ•œ๋‹ค. ์ œ์•ˆํ•œ ๋ชจ๋ธ์€ ๊ฐ€์‹œ๊ฒฝ๋กœ ๋ฐ ๋น„๊ฐ€์‹œ๊ฒฝ๋กœ์—์„œ์˜ ์ฑ„๋„ ํŠน์„ฑ์„ ๊ณ ๋ คํ•˜์—ฌ ์ž ์žฌ์ ์ธ ํ›„๋ณด ์ƒํƒœ๋“ค์„ ์ง€๋‹Œ๋‹ค. ํ•œ ์ˆœ๊ฐ„์˜ ์ˆ˜์‹  ์‹ ํ˜ธ ์„ธ๊ธฐ ์ธก์ •์น˜์— ๋Œ€ํ•ด ๊ฐ ๊ธฐ์ค€ ๊ธฐ์ง€๊ตญ๋ณ„๋กœ ์ตœ์ ์˜ ๊ฒฝ๋กœ์†์‹ค ๋ชจ๋ธ ์ƒํƒœ๋ฅผ ๊ฒฐ์ •ํ•˜๋Š” ํšจ์œจ์ ์ธ ๋ฐฉ์•ˆ์„ ์ œ์‹œํ•œ๋‹ค. ์ด๋ฅผ ์œ„ํ•ด ๊ธฐ์ง€๊ตญ๋ณ„ ๊ฒฝ๋กœ์†์‹ค๋ชจ๋ธ ์ƒํƒœ์˜ ์กฐํ•ฉ์— ๋”ฐ๋ฅธ ์ธก์œ„ ๊ฒฐ๊ณผ๋ฅผ ํ‰๊ฐ€ํ•  ์ง€ํ‘œ๋กœ์„œ ๋น„์šฉํ•จ์ˆ˜๋ฅผ ์ •์˜ํ•˜์˜€๋‹ค. ๊ฐ ๊ธฐ์ง€๊ตญ๋ณ„ ์ตœ์ ์˜ ์ฑ„๋„ ๋ชจ๋ธ์„ ์ฐพ๋Š”๋ฐ ํ•„์š”ํ•œ ๊ณ„์‚ฐ ๋ณต์žก๋„๋Š” ๊ธฐ์ง€๊ตญ ์ˆ˜์˜ ์ฆ๊ฐ€์— ๋”ฐ๋ผ ๊ธฐํ•˜๊ธ‰์ˆ˜์ ์œผ๋กœ ์ฆ๊ฐ€ํ•˜๋Š”๋ฐ, ์œ ์ „ ์•Œ๊ณ ๋ฆฌ์ฆ˜์„ ์ด์šฉํ•œ ํƒ์ƒ‰์„ ์ ์šฉํ•˜์—ฌ ๊ณ„์‚ฐ๋Ÿ‰์„ ์–ต์ œํ•˜์˜€๋‹ค. ์‹ค๋‚ด ๊ด‘์„ ์ถ”์  ๋ชจ์˜์‹คํ—˜์„ ํ†ตํ•œ ๊ฒ€์ฆ๊ณผ ์‹ค์ธก ๊ฒฐ๊ณผ๋ฅผ ์ด์šฉํ•œ ๊ฒ€์ฆ์„ ์ง„ํ–‰ํ•˜์˜€์œผ๋ฉฐ, ์ œ์•ˆํ•œ ๋ฐฉ์•ˆ์€ ์‹ค์ œ ์‹ค๋‚ด ํ™˜๊ฒฝ์—์„œ ๊ธฐ์กด์˜ ๊ธฐ๋ฒ•๋“ค์— ๋น„ํ•ด ์œ„์น˜ ์ถ”์ • ์˜ค์ฐจ๋ฅผ ์•ฝ 31% ๊ฐ์†Œ์‹œ์ผฐ์œผ๋ฉฐ ํ‰๊ท ์ ์œผ๋กœ 1.92 m ์ˆ˜์ค€์˜ ์ •ํ™•๋„๋ฅผ ๋‹ฌ์„ฑํ•จ์„ ํ™•์ธํ–ˆ๋‹ค. ๋งˆ์ง€๋ง‰์œผ๋กœ FTM ํ”„๋กœํ† ์ฝœ์„ ์ด์šฉํ•œ ์‹ค๋‚ด ์œ„์น˜ ์ถ”์  ์•Œ๊ณ ๋ฆฌ์ฆ˜์— ๋Œ€ํ•ด ์—ฐ๊ตฌํ•˜์˜€๋‹ค. ์Šค๋งˆํŠธํฐ์˜ ๋‚ด์žฅ ๊ด€์„ฑ ์„ผ์„œ์™€ ์™€์ดํŒŒ์ด ํ†ต์‹ ์—์„œ ์ œ๊ณตํ•˜๋Š” FTM ํ”„๋กœํ† ์ฝœ์„ ํ†ตํ•œ ๊ฑฐ๋ฆฌ ์ถ”์ •์„ ์ด์šฉํ•˜์—ฌ ์‹ค๋‚ด์—์„œ ์‚ฌ์šฉ์ž์˜ ์œ„์น˜๋ฅผ ์ถ”์ ํ•  ์ˆ˜ ์žˆ๋‹ค. ํ•˜์ง€๋งŒ ์‹ค๋‚ด์˜ ๋ณต์žกํ•œ ๋‹ค์ค‘๊ฒฝ๋กœ ํ™˜๊ฒฝ์œผ๋กœ ์ธํ•œ ํ”ผํฌ ๊ฒ€์ถœ ์‹คํŒจ๋Š” ๊ฑฐ๋ฆฌ ์ธก์ •์น˜์— ํŽธํ–ฅ์„ฑ์„ ์œ ๋ฐœํ•œ๋‹ค. ๋˜ํ•œ ์‚ฌ์šฉํ•˜๋Š” ๋””๋ฐ”์ด์Šค์˜ ์ข…๋ฅ˜์— ๋”ฐ๋ผ ์˜ˆ์ƒ์น˜ ๋ชปํ•œ ๊ฑฐ๋ฆฌ ์˜ค์ฐจ๊ฐ€ ๋ฐœ์ƒํ•  ์ˆ˜์žˆ๋‹ค. ๋ณธ ๋…ผ๋ฌธ์—์„œ๋Š” ์‹ค์ œ ํ™˜๊ฒฝ์—์„œ FTM ๊ฑฐ๋ฆฌ ์ถ”์ •์„ ์ด์šฉํ•  ๋•Œ ๋ฐœ์ƒํ•  ์ˆ˜ ์žˆ๋Š” ์˜ค์ฐจ๋“ค์„ ๊ณ ๋ คํ•˜๊ณ  ์ด๋ฅผ ๋ณด์ƒํ•˜๋Š” ๋ฐฉ์•ˆ์— ๋Œ€ํ•ด ์ œ์‹œํ•œ๋‹ค. ํ™•์žฅ ์นผ๋งŒ ํ•„ํ„ฐ์™€ ๊ฒฐํ•ฉํ•˜์—ฌ FTM ๊ฒฐ๊ณผ๋ฅผ ์‚ฌ์ „ํ•„ํ„ฐ๋ง ํ•˜์—ฌ ์ด์ƒ๊ฐ’์„ ์ œ๊ฑฐํ•˜๊ณ , ๊ฑฐ๋ฆฌ ์ธก์ •์น˜์˜ ํŽธํ–ฅ์„ฑ์„ ์ œ๊ฑฐํ•˜์—ฌ ์œ„์น˜ ์ถ”์  ์ •ํ™•๋„๋ฅผ ํ–ฅ์ƒ์‹œํ‚จ๋‹ค. ์‹ค๋‚ด์—์„œ์˜ ์‹คํ—˜ ๊ฒฐ๊ณผ ์ œ์•ˆํ•œ ์•Œ๊ณ ๋ฆฌ์ฆ˜์€ ๊ฑฐ์น˜ ์ธก์ •์น˜์˜ ํŽธํ–ฅ์„ฑ์„ ์•ฝ 44-65% ๊ฐ์†Œ์‹œ์ผฐ์œผ๋ฉฐ ์ตœ์ข…์ ์œผ๋กœ ์‚ฌ์šฉ์ž์˜ ์œ„์น˜๋ฅผ ์„œ๋ธŒ๋ฏธํ„ฐ๊ธ‰์œผ๋กœ ์ถ”์ ํ•  ์ˆ˜ ์žˆ์Œ์„ ๊ฒ€์ฆํ–ˆ๋‹ค.Indoor location-based services (LBS) can be combined with various applications such as indoor navigation for smartphone users, resource management in smart factories, and autonomous driving of robots. It is also indispensable for Internet of Things (IoT) applications. For various LBS, accurate location information is essential. Therefore, a proper ranging and positioning algorithm is important. For outdoors, the global navigation satellite system (GNSS) is available to provide position information. However, the GNSS is inappropriate indoors owing to the issue of the blocking of the signals from satellites. It is necessary to develop a technology that can replace GNSS in GNSS-denied environments. Among the various alternative systems, the one of promising technology is to use a Wi-Fi system that has already been applied to many commercial devices, and the infrastructure is in place in many regions. In this dissertation, Wi-Fi based indoor localization methods are presented. In the specific, I propose the three major issues related to accurate indoor localization using received signal strength (RSS) and fine timing measurement (FTM) protocol in the 802.11 standard for my dissertation topics. First, I propose a hybrid localization algorithm to boost the accuracy of range-based localization by improving the ranging accuracy under indoor non-line-of-sight (NLOS) conditions. I replaced the ranging part of the rule-based localization method with a deep regression model that uses data-driven learning with dual-band received signal strength (RSS). The ranging error caused by the NLOS conditions was effectively reduced by using the deep regression method. As a consequence, the positioning error could be reduced under NLOS conditions. The performance of the proposed method was verified through a ray-tracing-based simulation for indoor spaces. The proposed scheme showed a reduction in the positioning error of at least 22.3% in terms of the median root mean square error. Next, I study on positioning algorithm that considering NLOS conditions for each APs, using single band RSS measurement. The single band RSS information is widely used for indoor localization because they can be easily implemented by using existing infrastructure like Wi-Fi, Blutooth, or Zigbee. However, range estimation with a single pathloss model produces considerable errors, which degrade the positioning performance. This problem mainly arises because the single pathloss model cannot reflect diverse indoor radio wave propagation characteristics. In this study, I develop a new overlapping multi-state model to consider multiple candidates of pathloss models including line-of-sight (LOS) and NLOS states, and propose an efficient way to select a proper model for each reference node involved in the localization process. To this end, I formulate a cost function whose value varies widely depending on the choice of pathloss model of each access point. Because the computational complexity to find an optimal channel model for each reference node exponentially increases with the number of reference nodes, I apply a genetic algorithm to significantly reduce the complexity so that the proposed method can be executed in real-time. Experimental validations with ray-tracing simulations and RSS measurements at a real site confirm the improvement of localization accuracy for Wi-Fi in indoor environments. The proposed method achieves up to 1.92~m mean positioning error under a practical indoor environment and produces a performance improvement of 31.09\% over the benchmark scenario. Finally, I investigate accurate indoor tracking algorithm using FTM protocol in this dissertation. By using the FTM ranging and the built-in sensors in a smartphone, it is possible to track the user's location in indoor. However, the failure of first peak detection due to the multipath effect causes a bias in the FTM ranging results in the practical indoor environment. Additionally, the unexpected ranging error dependent on device type also degrades the indoor positioning accuracy. In this study, I considered the factors of ranging error in the FTM protocol in practical indoor environment, and proposed a method to compensate ranging error. I designed an EKF-based tracking algorithm that adaptively removes outliers from the FTM result and corrects bias to increase positioning accuracy. The experimental results verified that the proposed algorithm reduces the average ofthe ranging bias by 43-65\% in an indoor scenarios, and can achieve the sub-meter accuracy in average route mean squared error of user's position in the experiment scenarios.Abstract i Contents iv List of Tables vi List of Figures vii 1 INTRODUCTION 1 2 Hybrid Approach for Indoor Localization Using Received Signal Strength of Dual-BandWi-Fi 6 2.1 Motivation 6 2.2 Preliminary 8 2.3 System model 11 2.4 Proposed Ranging Method 13 2.5 Performance Evaluation 16 2.5.1 Ray-Tracing-Based Simulation 16 2.5.2 Analysis of the Ranging Accuracy 21 2.5.3 Analysis of the Neural Network Structure 25 2.5.4 Analysis of Positioning Accuracy 26 2.6 Summary 29 3 Genetic Algorithm for Path Loss Model Selection in Signal Strength Based Indoor Localization 31 3.1 Motivation 31 3.2 Preliminary 34 3.2.1 RSS-based Ranging Techniques 35 3.2.2 Positioning Technique 37 3.3 Proposed localization method 38 3.3.1 Localization Algorithm with Overlapped Multi-State Path Loss Model 38 3.3.2 Localization with Genetic Algorithm-Based Search 41 3.4 Performance evaluation 46 3.4.1 Numerical simulation 50 3.4.2 Experimental results 56 3.5 Summary 60 4 Indoor User Tracking with Self-calibrating Range Bias Using FTM Protocol 62 4.1 Motivation 62 4.2 Preliminary 63 4.2.1 FTM ranging 63 4.2.2 PDR-based trajectory estimation 65 4.3 EKF design for adaptive compensation of ranging bias 66 4.4 Performance evaluation 69 4.4.1 Experimental scenario 69 4.4.2 Experimental results 70 4.5 Summary 75 5 Conclusion 76 Abstract (In Korean) 89๋ฐ•

    Clinical Characteristics of Monomorphic Post-transplant Lymphoproliferative Disorders

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    Post-transplant lymphoproliferative disorders (PTLD) are a heterogeneous group of lymphoproliferative disorders associated with immunosuppression and Epstein-Barr virus infection. PTLD is classified into three major categories: early lesions, polymorphic PTLD, and monomorphic PTLD. The majority of monomorphic PTLD cases are non-Hodgkin's lymphoma of B-cell origin. This retrospective study was conducted to investigate the incidence, clinical manifestation, treatment, and outcomes of monomorphic PTLD among 5,817 recipients of solid organ or allogeneic hematopoietic stem cell transplantation from five institutions. Fourteen patients with monomorphic PTLD were identified (male:female 11:3; median age 42.6 yr, range 24-60). The overall incidence rate was 0.24%. The most common disease type was diffuse large B cell lymphoma (n=7). The median time between the transplant and diagnosis of PTLD was 85.8 months. However, all cases of PTLD after allogeneic hematopoietic stem cell transplantation occurred within 1 yr after transplantation. Ten of the 14 patients had EBV-positive tumor. Fourteen patients received combination systemic chemotherapy and four patients were treated with radiation therapy. Ten patients achieved a complete response (CR) and two patients a partial response (PR). The median follow-up period for surviving patients was 36.6 months. Nine patients remain alive (eight CR, one PR). Nine of 11 solid organ transplantations preserved graft function. The present study indicates a lower incidence rate and a longer median time before the development of PTLD than those of previous reports. Careful monitoring was needed after allogeneic hematopoietic stem cell transplantation for PTLD

    To the Edge of M87 and Beyond: Spectroscopy of Intracluster Globular Clusters and Ultra Compact Dwarfs in the Virgo Cluster

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    We present the results from a wide-field spectroscopic survey of globular clusters (GCs) in the Virgo Cluster. We obtain spectra for 201 GCs and 55 ultracompact dwarfs (UCDs) using the Hectospec on the Multiple Mirror Telescope, and derive their radial velocities. We identify 46 genuine intracluster GCs (IGCs), not associated with any Virgo galaxies, using the 3D GMM test on the spatial and radial velocity distribution.They are located at the projected distance 200 kpc โ‰ฒ\lesssim R โ‰ฒ\lesssim 500 kpc from the center of M87. The radial velocity distribution of these IGCs shows two peaks, one at vrv_{\rm r} = 1023 km sโˆ’1^{-1} associated with the Virgo main body, and another at vrv_{\rm r} = 36 km sโˆ’1^{-1} associated with the infalling structure. The velocity dispersion of the IGCs in the Virgo main body is ฯƒGCโˆผ\sigma_{\rm{GC}} \sim 314 km sโˆ’1^{-1}, which is smoothly connected to the velocity dispersion profile of M87 GCs, but much lower than that of dwarf galaxies in the same survey field, ฯƒdwarfโˆผ\sigma_{\rm{dwarf}} \sim 608 km sโˆ’1^{-1}. The UCDs are more centrally concentrated on massive galaxies, M87, M86, and M84. The radial velocity dispersion of the UCD system is much smaller than that of dwarf galaxies. Our results confirm the large-scale distribution of Virgo IGCs indicated by previous photometric surveys. The color distribution of the confirmed IGCs shows a bimodality similar to that of M87 GCs. This indicates that most IGCs are stripped off from dwarf galaxies and some from massive galaxies in the Virgo.Comment: 19 pages, 20 figures, 8 tables, accepted for publication in Ap

    A search for exoplanets around north circumpolar stars. VII. Detection of planetary companion orbiting the largest host star HD 18438

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    We have been conducting a exoplanet search survey using Bohyunsan Observatory Echelle Spectrograph (BOES) for the last 18 years. We present the detection of exoplanet candidate in orbit around HD 18438 from high-precision radial velocity (RV) mesurements. The target was already reported in 2018 (Bang et al. 2018). They conclude that the RV variations with a period of 719 days are likely to be caused by the pulsations because the Lomb-Scargle periodogram of HIPPARCOS photometric and Ha EW variations for HD 18438 show peaks with periods close to that of RV variations and there were no correlations between bisectors and RV measurements. However, the data were not sufficient to reach a firm conclusion. We obtained more RV data for four years. The longer time baseline yields a more accurate determination with a revised period of 803 +/- 5 days and the planetary origin of RV variations with a minimum planetary companion mass of 21 +/- 1 MJup. Our current estimate of the stellar parameters for HD 18438 makes it currently the largest star with a planetary companion.Comment: 6 pages, 4 figures, Accept to the Journal of the Korean Astronomical Societ

    UKIRT Widefield Infrared Survey for Fe+

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    The United Kingdom Infrared Telescope (UKIRT)Widefield Infrared Survey for Fe+ (UWIFE) is a 180 deg2 imaging survey of the first Galactic quadrant (7ร‚ยฐ < l < 62ร‚ยฐ |b| <1ร‚ยฐ.5) that uses a narrow-band filter centred on the [Fe II] 1.644-รŽยผm emission line. The [Fe II] 1.644-รŽยผm emission is a good tracer of dense, shock-excited gas, and the survey will probe violent environments around stars: star-forming regions, evolved stars, and supernova remnants, among others. The UWIFE survey is designed to complement the existing UKIRTW idefield Infrared Survey for H2 (UWISH2). The survey will also complement existing broad-band surveys. The observed images have a nominal 5ร? detection limit of 18.7 mag for point sources, with a median seeing of 0.83 arcsec. For extended sources, we estimate a surface brightness limit of 8.1 รƒ? 10-20 W m-2 arcsec-2. In this paper, we present an overview and some preliminary results of this survey. ร‚ยฉ 2014 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society

    Evaluation of therapeutic effects of natural killer (NK) cell-based immunotherapy in mice using in vivo apoptosis bioimaging with a caspase-3 sensor

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    Natural killer (NK) cellรข based immunotherapy is a promising strategy for cancer treatment, and caspaseรข 3 is an important effector molecule in NK cellรข mediated apoptosis in cancers. Here, we evaluated the antitumor effects of NK cellรข based immunotherapy by serial noninvasive imaging of apoptosis using a caspaseรข 3 sensor in mice with human glioma xenografts. Human glioma cells expressing both a caspaseรข 3 sensor as a surrogate marker for caspaseรข 3 activation and Renilla luciferase (Rluc) as a surrogate marker for cell viability were established and referred to as D54รข CR cells. Human NK92 cells were used as effector cells. Treatment with NK92 cells resulted in a timeรข and effector numberรข dependent increase in bioluminescence imaging (BLI) activity of the caspaseรข 3 sensor in D54รข CR cells in vitro. Caspaseรข 3 activation by NK92 treatment was blocked by Zรข VAD treatment in D54รข CR cells. Transfusion of NK92 cells induced an increase of the BLI signal by caspaseรข 3 activation in a doseรข and timeรข dependent manner in D54รข CR tumorรข bearing mice but not in PBSรข treated mice. Accordingly, sequential BLI with the Rluc reporter gene revealed marked retardation of tumor growth in the NK92รข treatment group but not in the PBSรข treatment group. These data suggest that noninvasive imaging of apoptosis with a caspaseรข 3 sensor can be used as an effective tool for evaluation of therapeutic efficacy as well as for optimization of NK cellรข based immunotherapy.รข Lee, H. W., Singh, T. D., Lee, S.รข W., Ha, J.รข H., Rehemtulla, A., Ahn, B.รข C., Jeon, Y.รข H., Lee, J. Evaluation of therapeutic effects of natural killer (NK) cellรข based immunotherapy in mice using in vivo apoptosis bioimaging with a caspaseรข 3 sensor. FASEB J. 28, 2932รข 2941 (2014). www.fasebj.orgPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154541/1/fsb2fj13243014.pd

    Microlensing Detections of Planets in Binary Stellar Systems

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    We demonstrate that microlensing can be used for detecting planets in binary stellar systems. This is possible because in the geometry of planetary binary systems where the planet orbits one of the binary component and the other binary star is located at a large distance, both planet and secondary companion produce perturbations at a common region around the planet-hosting binary star and thus the signatures of both planet and binary companion can be detected in the light curves of high-magnification lensing events. We find that identifying planets in binary systems is optimized when the secondary is located in a certain range which depends on the type of the planet. The proposed method can detect planets with masses down to one tenth of the Jupiter mass in binaries with separations <~ 100 AU. These ranges of planet mass and binary separation are not covered by other methods and thus microlensing would be able to make the planetary binary sample richer.Comment: 5 pages, two figures in JPG forma
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